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Institute for Plant SciencesAG Hildebrandt

2023-2024

  1. Angermann C, Heinemann B, Hansen J, Töpfer N, Braun HP, Hildebrandt TM (2024) Proteome reorganization and amino acid metabolism during germination and seedling establishment in Lupinus albus. Journal of Experimental Botany. https://doi.org/10.1093/jxb/erae197
  2. Kmiecik SW, Shi;Q, Chen, Y-G, Moormann J, Hildebrandt TM, Schade A, Fischer M, Kim KQ (2023) Crafting figures to describe cellular processes. Trends in biochemical sciences 48, 491-494. https://doi.org/10.1016/j.tibs.2022.09.004
  3. Freke R, Heinemann B, Hakim SE, Witte CP, Herde M, Hildebrandt TM, Franke J (2023) Isotope-guided metabolomics reveals divergent incorporation of valine into different flavor precursor classes in chives. ChemBioChem, e202300056. https://doi.org/10.1002/cbic.202300056

2020-2022

  1. Moormann J, Heinemann B, Hildebrandt TM (2022) News about amino acid metabolism in plant-microbe interactions. Trends in biochemical sciences 47 (10):839–850. https://doi.org/10.1016/j.tibs.2022.07.001.
  2. Brito DS, Quinhones CGS, Neri-Silva R, Heinemann B, Schertl P, Cavalcanti JHF, Eubel H, Hildebrandt T, Nunes-Nesi A, Braun H-P, Araújo WL (2022) The role of the electron-transfer flavoprotein: ubiquinone oxidoreductase following carbohydrate starvation in Arabidopsis cell cultures. Plant cell reports 41 (2):431–446. https://doi.org/10.1007/s00299-021-02822-1.
  3. Heinemann B, Künzler P, Eubel H, Braun H-P, Hildebrandt TM (2021) Estimating the number of protein molecules in a plant cell: protein and amino acid homeostasis during drought. Plant physiology 185 (2):385–404. https://doi.org/10.1093/plphys/kiaa050.
  4. Moseler A, Kruse I, Maclean AE, Pedroletti L, Franceschetti M, Wagner S, Wehler R, Fischer-Schrader K, Poschet G, Wirtz M, Dörmann P, Hildebrandt TM, Hell R, Schwarzländer M, Balk J, Meyer AJ (2021) The function of glutaredoxin GRXS15 is required for lipoyl-dependent dehydrogenases in mitochondria. Plant physiology 186 (3):1507–1525. https://doi.org/10.1093/plphys/kiab172.
  5. Heinemann B, Hildebrandt TM (2021) The role of amino acid metabolism in signaling and metabolic adaptation to stress-induced energy deficiency in plants. Journal of experimental botany 72 (13):4634–4645. https://doi.org/10.1093/jxb/erab182.
  6. Fuchs P, Rugen N, Carrie C, Elsässer M, Finkemeier I, Giese J, Hildebrandt TM, Kühn K, Maurino VG, Ruberti C, Schallenberg-Rüdinger M, Steinbeck J, Braun H-P, Eubel H, Meyer EH, Müller-Schüssele SJ, Schwarzländer M (2020) Single organelle function and organization as estimated from Arabidopsis mitochondrial proteomics. The Plant journal : for cell and molecular biology 101 (2):420–441. https://doi.org/10.1111/tpj.14534.

2017-2019

  1. Farhat N, Hichri S, Hildebrandt TM, Debez A, Braun H-P (2019) Composition and Stability of the Oxidative Phosphorylation System in the Halophile Plant Cakile maritima. Frontiers in plant science (10):1010. https://doi.org/10.3389/fpls.2019.01010.
  2. Batista-Silva W, Heinemann B, Rugen N, Nunes-Nesi A, Araújo WL, Braun H-P, Hildebrandt TM (2019) The role of amino acid metabolism during abiotic stress release. Plant, cell & environment 42 (5):1630–1644. https://doi.org/10.1111/pce.13518.
  3. Brandt S, Fachinger S, Tohge T, Fernie AR, Braun H-P, Hildebrandt TM (2018) Extended darkness induces internal turnover of glucosinolates in Arabidopsis thaliana leaves. PloS one 13 (8):e0202153. https://doi.org/10.1371/journal.pone.0202153.
  4. Lorenz C, Brandt S, Borisjuk L, Rolletschek H, Heinzel N, Tohge T, Fernie AR, Braun H-P, Hildebrandt TM (2018) The Role of Persulfide Metabolism During Arabidopsis Seed Development Under Light and Dark Conditions. Frontiers in plant science (9):1381. https://doi.org/10.3389/fpls.2018.01381.
  5. Hildebrandt TM (2018) Synthesis versus degradation: directions of amino acid metabolism during Arabidopsis abiotic stress response. Plant molecular biology 98 (2):121–135. https://doi.org/10.1007/s11103-018-0767-0.
  6. Belghith I, Senkler J, Hildebrandt T, Abdelly C, Braun H-P, Debez A (2018) Comparative analysis of salt-induced changes in the root proteome of two accessions of the halophyte Cakile maritima. Plant Physiology and Biochemistry 130 (1):20–29. https://doi.org/10.1016/j.plaphy.2018.06.029.
  7. Cavalcanti JHF, Quinhones CGS, Schertl P, Brito DS, Eubel H, Hildebrandt T, Nunes-Nesi A, Braun H-P, Araújo WL (2017) Differential impact of amino acids on OXPHOS system activity following carbohydrate starvation in Arabidopsis cell suspensions. Physiologia plantarum 161 (4):451–467. https://doi.org/10.1111/ppl.12612.
  8. Luna-Sánchez M, Hidalgo-Gutiérrez A, Hildebrandt TM, Chaves-Serrano J, Barriocanal-Casado E, Santos-Fandila Á, Romero M, Sayed RK, Duarte J, Prokisch H, Schuelke M, Distelmaier F, Escames G, Acuña-Castroviejo D, López LC (2017) CoQ deficiency causes disruption of mitochondrial sulfide oxidation, a new pathomechanism associated with this syndrome. EMBO molecular medicine 9 (1):78–95. https://doi.org/10.15252/emmm.201606345.
  9. Senkler J, Senkler M, Eubel H, Hildebrandt T, Lengwenus C, Schertl P, Schwarzländer M, Wagner S, Wittig I, Braun H-P (2017) The mitochondrial complexome of Arabidopsis thaliana. The Plant journal : for cell and molecular biology 89 (6):1079–1092. https://doi.org/10.1111/tpj.13448.

2014-2016

  1. Höfler S, Lorenz C, Busch T, Brinkkötter M, Tohge T, Fernie AR, Braun H-P, Hildebrandt TM (2016) Dealing with the sulfur part of cysteine: four enzymatic steps degrade l-cysteine to pyruvate and thiosulfate in Arabidopsis mitochondria. Physiologia plantarum 157 (3):352–366. https://doi.org/10.1111/ppl.12454.
  2. Schwender J, Hebbelmann I, Heinzel N, Hildebrandt T, Rogers A, Naik D, Klapperstück M, Braun H-P, Schreiber F, Denolf P, Borisjuk L, Rolletschek H (2015) Quantitative Multilevel Analysis of Central Metabolism in Developing Oilseeds of Oilseed Rape during in Vitro Culture. Plant physiology 168 (3):828–848. https://doi.org/10.1104/pp.15.00385.
  3. Birke H, Hildebrandt TM, Wirtz M, Hell R (2015) Sulfide detoxification in plant mitochondria. Methods in enzymology 555 (14):271–286. https://doi.org/10.1016/bs.mie.2014.11.027.
  4. Hildebrandt TM, Nunes Nesi A, Araújo WL, Braun H-P (2015) Amino Acid Catabolism in Plants. Molecular plant 8 (11):1563–1579. https://doi.org/10.1016/j.molp.2015.09.005.
  5. Krüßel L, Junemann J, Wirtz M, Birke H, Thornton JD, Browning LW, Poschet G, Hell R, Balk J, Braun H-P, Hildebrandt TM (2014) The mitochondrial sulfur dioxygenase ETHYLMALONIC ENCEPHALOPATHY PROTEIN1 is required for amino acid catabolism during carbohydrate starvation and embryo development in Arabidopsis. Plant physiology 165 (1):92–104. https://doi.org/10.1104/pp.114.239764.

2011-2013

  1. Hildebrandt TM, Di Meo I, Zeviani M, Viscomi C, Braun H-P (2013) Proteome adaptations in Ethe1-deficient mice indicate a role in lipid catabolism and cytoskeleton organization via post-translational protein modifications. Bioscience reports 33 (4):e0052. https://doi.org/10.1042/BSR20130051.
  2. Welchen E, Hildebrandt TM, Lewejohann D, Gonzalez DH, Braun H-P (2012) Lack of cytochrome c in Arabidopsis decreases stability of Complex IV and modifies redox metabolism without affecting Complexes I and III. Biochimica et biophysica acta 1817 (7):990–1001. https://doi.org/10.1016/j.bbabio.2012.04.008.
  3. Jonietz C, Forner J, Hildebrandt T, Binder S (2011) RNA PROCESSING FACTOR3 is crucial for the accumulation of mature ccmC transcripts in mitochondria of Arabidopsis accession Columbia. Plant physiology 157 (3):1430–1439. https://doi.org/10.1104/pp.111.181552.
  4. Hildebrandt TM (2011) Modulation of sulfide oxidation and toxicity in rat mitochondria by dehydroascorbic acid. Biochimica et biophysica acta 1807 (9):1206–1213. https://doi.org/10.1016/j.bbabio.2011.06.003.
  5. Farese S, Stauffer E, Kalicki R, Hildebrandt T, Frey BM, Frey FJ, Uehlinger DE, Pasch A (2011) Sodium thiosulfate pharmacokinetics in hemodialysis patients and healthy volunteers. Clinical journal of the American Society of Nephrology 6 (6):1447–1455. https://doi.org/10.2215/CJN.10241110.

2008-2010

  1. Viscomi C, Burlina AB, Dweikat I, Savoiardo M, Lamperti C, Hildebrandt T, Tiranti V, Zeviani M (2010) Combined treatment with oral metronidazole and N-acetylcysteine is effective in ethylmalonic encephalopathy. Nature medicine 16 (8):869–871. https://doi.org/10.1038/nm.2188.
  2. Hildebrandt T, Grieshaber MK (2009) Die vielen Seiten des Sulfids. Tödlich und doch lebensnotwendig. Biologie in unserer Zeit 39 (5):328–334. https://doi.org/10.1002/biuz.200910403.
  3. Tiranti V, Viscomi C, Hildebrandt T, Di Meo I, Mineri R, Tiveron C, Levitt MD, Prelle A, Fagiolari G, Rimoldi M, Zeviani M (2009) Loss of ETHE1, a mitochondrial dioxygenase, causes fatal sulfide toxicity in ethylmalonic encephalopathy. Nature medicine 15 (2):200–205. https://doi.org/10.1038/nm.1907.
  4. Krueger S, Niehl A, Lopez Martin MC, Steinhauser D, Donath A, Hildebrandt T, Romero LC, Hoefgen R, Gotor C, Hesse H (2009) Analysis of cytosolic and plastidic serine acetyltransferase mutants and subcellular metabolite distributions suggests interplay of the cellular compartments for cysteine biosynthesis in Arabidopsis. Plant, cell & environment 32 (4):349–367. https://doi.org/10.1111/j.1365-3040.2008.01928.x.
  5. Hildebrandt TM, Grieshaber MK (2008) Three enzymatic activities catalyze the oxidation of sulfide to thiosulfate in mammalian and invertebrate mitochondria. The FEBS journal 275 (13):3352–3361. https://doi.org/10.1111/j.1742-4658.2008.06482.x.
  6. Hildebrandt TM, Grieshaber MK (2008) Redox regulation of mitochondrial sulfide oxidation in the lugworm, Arenicola marina. The Journal of experimental biology 211 (16):2617–2623. https://doi.org/10.1242/jeb.019729.

For a full list of publications, please also see Google Scholar !